González Cardenete, Miguel Angel
Tenured Scientist (CSIC)
Email: migoncar@itq.upv.es
Miguel Angel González Cardenete studied Chemistry at the University of Valencia, Spain, where he obtained a Bachelor’s Degree in 1995, a Master’s Degree (1997, Excellent) and finally a Doctorate in Chemistry (2001, Excellent Cum laude, PhD Extraordinary award). In his Doctorate under the supervision of Professors Manuel Arnó Giribet and Ramón José Zaragozá Cardells, he developed the synthesis of a variety of skeletons of terpenoid natural products and started collaborations to study their biological properties. Also, he joined the group of Prof. Gerald Pattenden at the University of Nottingham (UK) to study radical cascade reactions for obtaining polycyclic systems. At the end of the Doctorate, he went back to the Pattenden’s group as Postdoctoral researcher and worked on a project for the synthesis of one of the most potent antitumor agents known to date, the Phorboxazole A. Then, he made a Postdoctoral stay with a Fulbright fellowship in the group of Prof. Emmanuel A. Theodorakis at the University of California, San Diego (USA).
After three years of postdoctoral research abroad, he returned to Spain to work as “Ramón y Cajal” researcher at the University of Valencia, where he worked in two research lines, development of synthetic methodology and medicinal chemistry from natural compounds. There, he worked as Assistant Professor and senior researcher. In 2015, he got a position as tenured scientist at the Spanish National Research Council (CSIC) and moved to the Institute of Chemical Technology.
Main lines of research:
- Sustainable synthesis of Natural Products, derivatives and analogues of pharmacological interest.
- Medicinal Chemistry
His research has led to more than 60 publications and conference communications and one patent.
His publication list as well as his h-index (h= 22, July 2023) can be seen in the following link: Publications in Scopus. (Link)
Relevant publications:
- Miguel A. González-Cardenete*, Natalia González-Zapata, Lucinda Boyd and Fatima Rivas “Discovery of novel bioactive tanshinones and carnosol analogues against breast cancer”, Cancers 2023, 15, 1318. Journal quartile (JCR2021) and position: Q1, 60/240. Category: ONCOLOGY; DOI: 10.3390/cancers15041318
- Miguel A. González-Cardenete*, Damir Hamulic, Francisco J. Miquel-Leal, Natalia Gonzalez-Zapata,Orlando J. Jimenez-Jarava, Yaneth M. Brand, Laura C. Restrepo-Mendez, Marlen Martinez-Gutierrez, Liliana A. Betancur-Galvis, and Maria L. Marin “Antiviral Profiling of C‑18- or C‑19-Functionalized Semisynthetic Abietane Diterpenoids”, Journal of Natural Products 2022, 85, 2044-2051. Journal quartile (JCR2021) and position: Q1, 38/238. Category: PLANT SCIENCES; DOI: 10.1021/acs.jnatprod.2c00464
- Miguel A. González-Cardenete*, Fatima Rivas, Rachel Bassett, Marco Stadler, Steffen Hering, José M. Padrón, Ramón J. Zaragozá, M. Auxiliadora Dea-Ayuela*, Biological Profiling of Semisynthetic C19‐Functionalized Ferruginol and Sugiol Analogues, Antibiotics 2021, 10, 184. Journal quartile and position: Q1, 68/279. Category: PHARMACOLOGY; DOI: 10.3390/antibiotics10020184
- Ramón J. Zaragozá*, Miguel A. González-Cardenete*, Synthesis of Bodinieric acids, both C-18 and C-19-Funtionalized Abietane Diterpenoids: DFT study of the key aldol reaction”, RSC Advances 2020, 10, 15015-15022. Journal quartile (JCR) and position: Q2, 81/179. Category: CHEMISTRY, MULTIDISCIPLINARY; DOI: 1039/d0ra02711a
- Damir Hamulić, Marco Stadler, Steffen Hering, José M. Padrón, Rachel Bassett, Fatima Rivas, Marco A. Loza-Mejía, M. Auxiliadora Dea-Ayuela, Miguel A. González-Cardenete*, “Synthesis and Biological studies of (+)-liquiditerpenoic acid A (abietopinoic acid) and representative analogs: SAR studies”, Journal of Natural Products 2019, 82, 823-831. Journal quartile and position: Q1, 32/234. Category: PLANT SCIENCES; DOI: 10.1021/acs.jnatprod.8b00884
- A. Dea-Ayuela, P. Bilbao-Ramos, F. Bolás-Fernández and Miguel A. González-Cardenete*, “Synthesis and Antileishmanial activity of C7- and C12-functionalized dehydroabietylamine derivatives”, European Journal Medicinal Chemistry 2016, 121, 445-450. Journal quartile and position: Q1, 4/60 (Decile 1). Category: CHEMISTRY, MEDICINAL; DOI: 10.1016/j.ejmech.2016.06.004
- Roa-Linares, Y. Brand, L. Agudelo, V. Tangarife, L. Betancur-Galvis, J. C. Gallego and Miguel A. González*, “Anti-Herpetic and Anti-Dengue Activity of (+)-Ferruginol analogues Synthesized from (+)-Dehydroabietylamine”, European Journal Medicinal Chemistry 2016, 108, 79-88. Journal quartile and position: Q1, 4/60 (Decile 1). Category: CHEMISTRY, MEDICINAL; DOI: 10.1016/j.ejmech.2015.11.009
- Miguel A. González*, “Aromatic Abietane Diterpenoids: Their Biological Activity and Synthesis”, Natural Product Reports 2015, 32, 684-704. Journal quartile and position: Q1, 1/59 (Decile 1). Category: CHEMISTRY, MEDICINAL; DOI: 10.1039/c4np00110a
- Miguel A. González*, “Synthetic Derivatives of Aromatic Abietane Diterpenoids and Their Biological Activities”, European Journal Medicinal Chemistry 2014, 87, 834-842. Journal quartile and position: Q1, 11/59. Category: CHEMISTRY, MEDICINAL; DOI: 10.1016/j.ejmech.2014.10.023
- Miguel A. González*, Ramón J. Zaragozá, “Synthesis of the Antiviral Abietane Diterpenoid (+)-Jiadifenoic acid C from Callitrisic acid (4-epidehydroabietic acid) isolated from Sandarac Resin”, Journal Natural Products 2014, 77, 2114-2117. Journal quartile and position: Q1, 7/59. Category: CHEMISTRY, MEDICINAL; DOI: 10.1021/np500569y
- Miguel A. González*, D. Perez-Guaita, J. Correa-Royero, B. Zapata, L. Agudelo, A. Mesa-Arango, L. Betancur-Galvis, “Synthesis and Biological Evaluation of Dehydroabietic acid derivatives”, European Journal Medicinal Chemistry 2010, 45, 811-816. Journal quartile and position: Q1, 11/54. Category: CHEMISTRY, MEDICINAL; DOI: 10.1016/j.ejmech.2009.10.010