Lhiaubet, Virginie Lyria

Tenured Scientist (CSIC)

Tel: +34 96 387 78 15

Virginie Lhiaubet-Vallet graduated from the University Paul Sabatier (Toulouse, France); in 2001, she defended her Doctoral Thesis untitled “Mechanisms of DNA damage photosensitized by drugs derived from aromatic ketones” supervised by Nicole Paillous and Nadia Chouini-Lalanne. In 2001, she was granted with an Individual Marie Curie Fellowship to join Prof. M. A. Miranda’s group at the Institute of Chemical Technology (ITQ) as a postdoctoral researcher. In 2008, she obtained a ‘‘Ramón y Cajal’’ contract; and since 2016, she is a Tenured Scientist of the Spanish National Research Council (CSIC).

Her main research interests are:

  • Interaction between light and biomolecules (particularly DNA) to obtain information on the molecular processes responsible for photosensitivity and to design new photoprotection tools
  • Study of DNA photodamage formation and repair (such as thymine dimers)
  • Design of photocages based on prodrug/profilter systems to allow a controlled photorelease of photosensitizing drugs together with a solar filter acting as protecting shield

 

ORCID number: 0000-0002-8205-8892

The list of its scientific publications, as well as its index h, can be seen in this link

 

Her scientific career has been recognized internationally in 2007 by the “Young Investigator Award of the European Society for Photobiology”, an outstanding award given biennially by the society to a scientist under 35 years old. In addition, Dr. Lhiaubet has given 2 plenary lectures, 15 invited lectures and 14 oral communications. She has been PI of 7 projects, including national and international projects. She has been the supervisor of 4 theses and is currently supervising 2 others. She has also tutored 6 postdoctoral students and 9 short-stays of PhD or graduated students.

In addition, she is the author of 66 publications, being corresponding author of 19 of them. Since her doctoral thesis, her research has been centered on the study of DNA damage and photochemistry of drugs and biomolecules. Thus, she participated in central contributions such as (i) the reductive photocycloreversion of azetidines as a model of DNA repair by (6-4) photolyase (Angew. Chem. Int. Ed. 2016, Chem. Eur. J. 2018) (ii) the discovery of the role of DNA lesions as intrinsic photosensitizer (Angew. Chem. Int. Ed. 2013, ACS Chem. Biol. 2018), (iii) the study of np* higher excited states of thymine (J. Am. Chem. Soc. 2013), (iv) establishing the energy of the excited triplet state of thymine in DNA (J. Am. Chem. Soc. 2006), (v) demonstrating the stereoselective quenching of ketoprofen triplet excited state in the presence of thymine (J. Am. Chem. Soc. 2005), (vi) the use of triplet excited states as probes for protein binding sites (J. Am. Chem. Soc. 2004).

 

Most successful publications in the last 10 years:

  1. A. B. Fraga-Timiraos, A. Francés-Monerris, G. M. Rodríguez-Muñiz, M. Navarrete-Miguel, M. A. Miranda, D. Roca-Sanjuan, V. Lhiaubet-Vallet “Experimental and theoretical study on the cycloreversion of a nucleobase-derived azetidine by photoinduced electron transfer” Chem. Eur. J. in press, doi: 10.1002/chem.201803298
  2. M.-D. Li, Z. Yan, R. Zhu, D. Lee Phillips, I. Aparici-Espert, V. Lhiaubet-Vallet, M. A. Miranda “Enhanced drug photosafety by interchromophoric interaction due to intramolecular charge separation” Chem. Eur. J. (2018) 24, 6654.
  3. I. Aparici-Espert, G. Garcia-Lainez, I. Andreu, M. A. Miranda, V. Lhiaubet-Vallet “Oxidatively generated lesions as internal photosensitizers for pyrimidine dimerization in DNA” ACS Chem. Biol. (2018), 13, 542.
  4. I. Aparici-Espert, M. C. Cuquerella, C. Paris, V. Lhiaubet-Vallet, M. A. Miranda “Photocages for protection and controlled release of bioactive compounds” Chem. Commun., (2016), 52, 14215.
  5. A. B. Fraga-Timiraos, V. Lhiaubet-Vallet, M. A. Miranda “Repair of a dimeric azetidine related to thymine–cytosine (6-4) photoproduct by electron transfer photoreduction” Angew. Chem. Int. Ed. (2016) 55, 6037.
  6. I. Aparici-Espert, A. Francés-Monerris, G. M. Rodríguez-Muñiz, D. Roca-Sanjuán, V. Lhiaubet-Vallet, Miguel A. Miranda “A combined experimental and theoretical approach to the photogeneration of 5,6-dihydropyrimidin-5-yl radicals in non aqueous media” J. Org. Chem. (2016), 81, 4031.
  7. V. Vendrell-Criado, G. Rodríguez-Muñiz, M. C. Cuquerella, V. Lhiaubet-Vallet, M. A. Miranda* “Photosensitization of DNA by 5-methyl-2-pyrimidone deoxyribonucleoside: (6-4) photoproduct as a possible Trojan horse” Angew. Chem. Int. Ed. (2013) 52, 6476.
  8. V. Vendrell-Criado, G. Rodríguez-Muñiz, M. Yamaji, V. Lhiaubet-Vallet, M. C. Cuquerella, M. A. Miranda “Two-photon chemistry from upper triplet states of thymine” J. Am. Chem. Soc. (2013) 135, 16714.
  9. G. Rodriguez-Muñiz, M. L. Marin, V. Lhiaubet-Vallet, M. A. Miranda “Reactivity of nucleosides with hydroxyl radical in non-aqueous medium” Chem. Eur. J. (2012) 18, 8024.
  10. M. C. Cuquerella, V. Lhiaubet-Vallet, J. Cadet, M. A. Miranda “Benzophenone photosensitized DNA damage” Acc. Chem. Res. (2012) 45, 1558.