VIP (very important paper): «Photosensitization of DNA by 5-Methyl-2-Pyrimidone Deoxyribonucleoside: (6-4) Photoproduct as a Possible Trojan Horse»
VIP (very important paper): Photosensitization of DNA by 5-Methyl-2-Pyrimidone Deoxyribonucleoside: (6-4) Photoproduct as a Possible Trojan Horse
by Victoria Vendrell-Criado, Dr. Gemma M. Rodríguez-Muñiz, Dr. M. Consuelo Cuquerella, Dr. Virginie Lhiaubet-Vallet*, Prof. Miguel A. Miranda* has now been published online.
Article first published online: 9 MAY 2013
DOI: 10.1002/anie.201302176
A (photo)sensitive subject: Combined agarose gel electrophoresis and photochemical studies show that 5-methyl-2-pyrimidone (see picture), the main chromophore of (6-4) photoproducts, behaves as a DNA photosensitizer. These results raise the question of whether the (6-4) lesions can act as Trojan horses, enhancing CPD formation and oxidative damage.
The article is available: