Proyecto 2: » Especies fotoactivas como sondas para proteínas»
Investigador principal: Miguel Ángel Miranda
- Lista de publicaciones:
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Vayá, I; Bueno, C. J.; Jiménez, M. C.; Miranda, M. A.
«Determination of enantiomeric compositions by Transient Absorption Spectroscopy using Proteins as Chiral Selectors.»
Chem. Eur. J. (2008), 14, 11284-11287.
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Andreu, I.; Delgado, J.; Espinos, A.; Perez-Ruiz, R.; Jimenez, M. C.; Miranda, M. A.
“Cycloreversion of Azetidines via Oxidative Electron Transfer. Steady-State and Time-Resolved Studies”
Org. Lett. (2008), 10, 5207-5210.
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Montanaro, Sara; Lhiaubet-Vallet, Virginie; Iesce, María Rosaria; Previtera, Lucio; Miranda, Miguel Ángel.
«A mechanistic study on the phototoxicity of atorvastatin: singlet oxygen generation by a phenanthrene-like photoproduct»
Chem. Res. Toxicol, (2009), 22, 173-178.
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Asins-Fabra, Belén, Andreu, Inmaculada, Jiménez, M. Consuelo, Miranda, Miguel A.
«Photoinduced processes in flurbiprofen-carprofen dyads.».
J. Photochem. Photobiol. A-Chem( 2009), 207, 52-57
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Rohacova, J.; Marín, M. L.; Martínez-Romero, A.; Díaz, L.; O’Connor, J.- E.;Gómez-Lechon, M. J.; Donato, M. T.; Castell J. V.; Miranda, M. A.
Fluorescent Benzofurazan-Cholic Acid Conjugates for in vitro Assessment of Bile Acid Uptake and Its Modulation by Drugs.»
ChemMedChem (2009), 4, 466-47
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Bueno, C. J.; Jiménez, M. C.; Miranda, M. A.
«In situ transient spectroscopy for the study of glucuronidase activity within serum albumin.»
J Phys Chem B, (2009), 113, 6861
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Montanaro, S.; Lhiaubet-Vallet, V. Jiménez, M. C.; Blanca, M.; Miranda, M. A.
«Photonucleophilic Addition of the epsilon-Amino Group of Lysine to a Triflusal Metabolite as a Mechanistic Key to Photoallergy Mediated by the Parent Drug.»
ChemMedChem (2009), 4, 1196-1202.
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Bartovsky, P.; Tormos,R; Miranda, M.A.
“Colchicine-protein interactions revealed by transient absorption spectroscopy after in situ photoisomerization to lumicolchicines”
Chem. Phys. Lett. (2009), 480, 305-308.
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Lhiaubet-Vallet, V.; Bosca, F.; Miranda, M. A.
“Photosensitized DNA Damage:The Case of Fluoroquinolones”
Photochem. Photobiol. (2009), 85, 861-868.
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Netto-Ferreira, J. C.; Lhiaubet-Vallet, V.; Bernardes, B. D.; Ferreira, A. B. B.; Miranda, M. A.
”Photosensitizing Properties of Triplet beta-Lapachones in Acetonitrile”
Solution Photochem. Photobiol. (2009), 85, 153-159.
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Salom-Roig, X. J.; Martinez, J.; Burguete, M. I.; Galindo, F.; Luis, S. V.; Miranda, M. A.; Morant-Minana, M. C.; Perez-Prieto, J. Chiral
“Synthetic pseudopeptidic derivatives as triplet excited state quenchers”
Tetrahedron Lett.( 2009), 50, 4859-4862.
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Bueno, C. J.; Jimenez, M. C.; Miranda, M. A.
”In Situ Transient Spectroscopy for the Study of Glucuronidase Activity within Serum Albumin”
J. Phys. Chem. B (2009), 113, 6861-6865.
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Rohacova, J.; Marin, M. L.; Martinez-Romero, A.; O’Connor, J. E.; Gomez-Lechon, M. J.; Donato, M. T.; Castell, J. V.; Miranda, M. A.
“Synthesis of new, UV-photoactive dansyl derivatives for flow cytometric studies on bile acid uptake”
Org. Biomol. Chem. (2009), 7, 4973-4980.
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Jornet, D.; Bartovsky, P.; Domingo, L. R.; Tormos, R.; Miranda, M. A.
”Experimental and Theoretical Studies on the Mechanism of Photochemical Hydrogen Transfer from 2-Aminobenzimidazole to n pi* and pi pi*Aromatic Ketones”
J. Phys. Chem. B (2010), 114, 11920-11926.
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Andreu, I.; Mayorga, C.; Miranda, M. A.
”Generation of reactive intermediates in photoallergic dermatitis”
Curr. Opin. Allergy Clin. Immunol. (2010), 10, 303-308.
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Viudes, V.; Bartovsky, P.; Domingo, L. R.; Tormos, R.; Miranda, M. A.
”Experimental and Theoretical (DFT) Characterization of the Excited States and N-Centered Radical Species Derived from 2-Aminobenzimidazole, the Core Substructure of a Family of Bioactive Compounds”
J. Phys. Chem. B (2010), 114, 6608-6613.
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Rohacova, J.; Marin, M. L.; Miranda, M. A.
”Complexes between Fluorescent Cholic Acid Derivatives and Human Serum Albumin. A Photophysical Approach To Investigate the Binding Behavior”
J. Phys. Chem. B (2010), 114, 4710-4716.
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Perez-Ruiz, R.; Bueno, C. J.; Jimenez, M. C.; Miranda, M. A.
”In situ Transient Absorption Spectroscopy to Assess Competition between Serum Albumin and Alpha-1-Acid Glycoprotein for Drug Transport”
J. Phys. Chem. Lett. (2010), 1, 829-833.
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Vaya, I.; Perez-Ruiz, R.; Lhiaubet-Vallet, V.; Jimenez, M. C.; Miranda, M. A.
”Drug-protein interactions assessed by fluorescence measurements in the real complexes and in model dyads”
Chem. Phys. Lett. (2010), 486, 147-153.
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Cuquerella, M. C.; Rohacova, J.; Marin, M. L.; Miranda, M. A.
”Stereodifferentiation in fluorescence quenching within cholic acid aggregates”
Chem. Commun. (2010), 46, 4965-4967.
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Netto-Ferreira, J. C.; Lhiaubet-Vallet, V.; da Silva, A. R.; da Silva, A. M.; Ferreira, A. B. B.; Miranda, M. A.
”The Photochemical Reactivity of Triplet beta-Lapachone-3-sulfonic Acid towards Biological Substrates”
J. Braz. Chem.Soc. (2010), 21, 966-972.
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Alonso, R.; Yamaji, M.; Jimenez, M. C.; Miranda, M. A.
”Enhanced Photostability of the Anthracene Chromophore in Aqueous Medium upon Protein Encapsulation”
J. Phys. Chem. B (2010), 114, 11363-11369.
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Jornet, D.; Tormos, R.; Miranda, M. A.
“Photobehavior of Mixed n pi*/pi pi* Triplets: Simultaneous Detection of the Two Transients, Solvent-Dependent Hydrogen Abstraction, and Reequilibration upon Protein Binding”
J. Phys. Chem. B (2011), 115, 10768-10774.
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Rohacova, J.; Sastre, G.; Marin, M. L.; Miranda, M. A.
“Dansyl Labeling To Modulate the Relative Affinity of Bile Acids for the Binding Sites of Human Serum Albumin”
J. Phys. Chem. B (2011), 115, 10518-10524.
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Alonso, R.; Jimenez, M. C.; Miranda, M. A.
“Stereodifferentiation in the Compartmentalized Photooxidation of a Protein-Bound Anthracene”
Org. Lett. (2011), 13, 3860-3863.
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Andreu, I.; Palumbo, F.; Tilocca, F.; Morera, I. M.; Bosca, F.; Miranda, M. A.
“Solvent Effects in Hydrogen Abstraction from Cholesterol by Benzophenone Triplet Excited” State
Org. Lett. (2011), 13, 4096-4099.
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Andreu, I.; Neshchadin, D.; Rico, E.; Griesser, M.; Samadi, A.; Morera, I. M.; Gescheidt, G.; Miranda, M. A.
“Probing Lipid Peroxidation by Using Linoleic Acid and Benzophenone”
Chem. Eur. J. (2011), 17, 10089-10096.
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Perez-Ruiz, R.; Alonso, R.; Nuin, E.; Andreu, I.; Jimenez, M. C.; Miranda, M. A.
”Naphthalene Triplet Excited State as a Probe for the Assessment of Drug Distribution in Binary Protein Systems”
J. Phys. Chem. B( 2011), 115, 4460-4468.
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Gomez-Mendoza, M.; Marin, M. L.; Miranda, M. A.
Dansyl Derivatives of Cholic “Acid as Tools to Build Speciation Diagrams for Sodium Cholate Aggregation”
J. Phys. Chem. Lett.( 2011), 2, 782-785.
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Marin, M.; Lhiaubet-Vallet, V.; Miranda, M. A.
“Site-Dependent Photo-Fries Rearrangement within Serum Albumins”
J.Phys. Chem. B (2011), 115, 2910-2915.
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Nuin, E.; Andreu, I.; Jose Torres, M.; Jimenez, M. C.; Miranda, M. A.
“Enhanced Photosafety of Cinacalcet upon Complexation with Serum Albumin”
J. Phys. Chem. B (2011), 115, 1158-1164.
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Marin, M.; Lhiaubet-Vallet, V.; Paris, C.; Yamaji, M.; Miranda, M. A.
”Photochemical and photophysical properties of dibenzoylmethane derivatives within protein”
Photochem. Photobiol. Sci. (2011), 10, 1474-1479.
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Marin, M.; Lhiaubet-Vallet, V.; Miranda, M. A.
”Enhanced Photochemical 6 pi Electrocyclization within the Lipophilic Protein Binding Site”
Org. Lett. (2012), 14, 1788-1791.
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Marin, M. L.; Santos-Juanes, L.; Arques, A.; Amat, A. M.; Miranda, M. A.
”Organic Photocatalysts for the Oxidation of Pollutants and Model Compounds”
Chem. Rev.( 2012), 112, 1710-1750.
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Bartovsky, P.; Domingo, L. R.; Jornet, D.; Tormos, R.; Miranda, M. A.
”The triplet excited state of the bioactive compound thiabendazole. Characterization and suitability as reporter for cyclodextrin complexation”
Chem. Phys. Lett.( 2012), 525-26, 166-170.
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Soldevila, S.; Bosca, F.
”Photoreactivity of Fluoroquinolones: Nature of Aryl Cations Generated in Water”
Org. Lett. (2012), 14, 3940-3943.
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Cuquerella, M. C.; Andreu, I.; Soldevila, S.; Bosca, F.
”Triplet Excimers of Fluoroquinolones in Aqueous Media”
J. Phys. Chem. A (2012), 116, 5030-5038.
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Bonancía, P.; Vayá, I.; Climent, M. J.; Gustavsson, T.; Markovitsi, D.; Jiménez, M. C.; Miranda, M. A.
”Excited-State Interactions in Diastereomeric Flurbiprofen–Thymine Dyads”
J. Phys. Chem. A (2012).
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Bonancía, P.; Vigara, L.; Galindo, F.; Luis, S. V.; Jiménez, M. C.; Miranda, M.
”A. Triplet Excited State Behavior of Naphthalene-Based Pseudopeptides in the Presence of Energy Donors”
J. Phys. Chem. B( 2012), 116, 9957 -9962.
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Perez-Ruiz, R.; Saez, J. A.; Domingo, L. R.; Jimenez, M. C.; Miranda, M. A.
”Ring splitting of azetidin-2-ones via radical anions”
Org. Biomol. Chem. (2012).
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Gomez-Mendoza, M.; Nuin, E.; Andreu, I.; Marin, M. L.; Miranda, M. A.
”Photophysical Probes To Assess the Potential of Cholic Acid Aggregates as Drug Carriers”
J. Phys. Chem. B (2012), 116, 10213-10218.
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Bosca, F.
”Seeking to Shed Some Light on the Binding of Fluoroquinolones to Albumins”
J. Phys. Chem. B (2012), 116, 3504-3511.
