Especies fotoactivas

Proyecto 2: ” Especies fotoactivas como sondas para proteínas”
Investigador principal: Miguel Ángel Miranda

    Lista de publicaciones:

  • Vayá, I; Bueno, C. J.; Jiménez, M. C.; Miranda, M. A.

    “Determination of enantiomeric compositions by Transient Absorption Spectroscopy using Proteins as Chiral Selectors.”

    Chem. Eur. J. (2008), 14, 11284-11287.

  • Andreu, I.; Delgado, J.; Espinos, A.; Perez-Ruiz, R.; Jimenez, M. C.; Miranda, M. A.

    “Cycloreversion of Azetidines via Oxidative Electron Transfer. Steady-State and Time-Resolved Studies”

    Org. Lett. (2008), 10, 5207-5210.

  • Montanaro, Sara; Lhiaubet-Vallet, Virginie; Iesce, María Rosaria; Previtera, Lucio; Miranda, Miguel Ángel.

    “A mechanistic study on the phototoxicity of atorvastatin: singlet oxygen generation by a phenanthrene-like photoproduct”

    Chem. Res. Toxicol, (2009), 22, 173-178.

  • Asins-Fabra, Belén, Andreu, Inmaculada, Jiménez, M. Consuelo, Miranda, Miguel A.

    “Photoinduced processes in flurbiprofen-carprofen dyads.”.

    J. Photochem. Photobiol. A-Chem( 2009), 207, 52-57

  • Rohacova, J.; Marín, M. L.; Martínez-Romero, A.; Díaz, L.; O’Connor, J.- E.;Gómez-Lechon, M. J.; Donato, M. T.; Castell J. V.; Miranda, M. A.

    Fluorescent Benzofurazan-Cholic Acid Conjugates for in vitro Assessment of Bile Acid Uptake and Its Modulation by Drugs.”

    ChemMedChem (2009), 4, 466-47

  • Bueno, C. J.; Jiménez, M. C.; Miranda, M. A.

    “In situ transient spectroscopy for the study of glucuronidase activity within serum albumin.”

    J Phys Chem B, (2009), 113, 6861

  • Montanaro, S.; Lhiaubet-Vallet, V. Jiménez, M. C.; Blanca, M.; Miranda, M. A.

    “Photonucleophilic Addition of the epsilon-Amino Group of Lysine to a Triflusal Metabolite as a Mechanistic Key to Photoallergy Mediated by the Parent Drug.”

    ChemMedChem (2009), 4, 1196-1202.

  • Bartovsky, P.; Tormos,R; Miranda, M.A.

    “Colchicine-protein interactions revealed by transient absorption spectroscopy after in situ photoisomerization to lumicolchicines”

    Chem. Phys. Lett. (2009), 480, 305-308.

  • Lhiaubet-Vallet, V.; Bosca, F.; Miranda, M. A.

    “Photosensitized DNA Damage:The Case of Fluoroquinolones”

    Photochem. Photobiol. (2009), 85, 861-868.

  • Netto-Ferreira, J. C.; Lhiaubet-Vallet, V.; Bernardes, B. D.; Ferreira, A. B. B.; Miranda, M. A.

    ”Photosensitizing Properties of Triplet beta-Lapachones in Acetonitrile”

    Solution Photochem. Photobiol. (2009), 85, 153-159.

  • Salom-Roig, X. J.; Martinez, J.; Burguete, M. I.; Galindo, F.; Luis, S. V.; Miranda, M. A.; Morant-Minana, M. C.; Perez-Prieto, J. Chiral

    “Synthetic pseudopeptidic derivatives as triplet excited state quenchers”

    Tetrahedron Lett.( 2009), 50, 4859-4862.

  • Bueno, C. J.; Jimenez, M. C.; Miranda, M. A.

    ”In Situ Transient Spectroscopy for the Study of Glucuronidase Activity within Serum Albumin”

    J. Phys. Chem. B (2009), 113, 6861-6865.

  • Rohacova, J.; Marin, M. L.; Martinez-Romero, A.; O’Connor, J. E.; Gomez-Lechon, M. J.; Donato, M. T.; Castell, J. V.; Miranda, M. A.

    “Synthesis of new, UV-photoactive dansyl derivatives for flow cytometric studies on bile acid uptake”

    Org. Biomol. Chem. (2009), 7, 4973-4980.

  • Jornet, D.; Bartovsky, P.; Domingo, L. R.; Tormos, R.; Miranda, M. A.

    ”Experimental and Theoretical Studies on the Mechanism of Photochemical Hydrogen Transfer from 2-Aminobenzimidazole to n pi* and pi pi*Aromatic Ketones”

    J. Phys. Chem. B (2010), 114, 11920-11926.

  • Andreu, I.; Mayorga, C.; Miranda, M. A.

    ”Generation of reactive intermediates in photoallergic dermatitis”

    Curr. Opin. Allergy Clin. Immunol. (2010), 10, 303-308.

  • Viudes, V.; Bartovsky, P.; Domingo, L. R.; Tormos, R.; Miranda, M. A.

    ”Experimental and Theoretical (DFT) Characterization of the Excited States and N-Centered Radical Species Derived from 2-Aminobenzimidazole, the Core Substructure of a Family of Bioactive Compounds”

    J. Phys. Chem. B (2010), 114, 6608-6613.

  • Rohacova, J.; Marin, M. L.; Miranda, M. A.

    ”Complexes between Fluorescent Cholic Acid Derivatives and Human Serum Albumin. A Photophysical Approach To Investigate the Binding Behavior”

    J. Phys. Chem. B (2010), 114, 4710-4716.

  • Perez-Ruiz, R.; Bueno, C. J.; Jimenez, M. C.; Miranda, M. A.

    ”In situ Transient Absorption Spectroscopy to Assess Competition between Serum Albumin and Alpha-1-Acid Glycoprotein for Drug Transport”

    J. Phys. Chem. Lett. (2010), 1, 829-833.

  • Vaya, I.; Perez-Ruiz, R.; Lhiaubet-Vallet, V.; Jimenez, M. C.; Miranda, M. A.

    ”Drug-protein interactions assessed by fluorescence measurements in the real complexes and in model dyads”

    Chem. Phys. Lett. (2010), 486, 147-153.

  • Cuquerella, M. C.; Rohacova, J.; Marin, M. L.; Miranda, M. A.

    ”Stereodifferentiation in fluorescence quenching within cholic acid aggregates”

    Chem. Commun. (2010), 46, 4965-4967.

  • Netto-Ferreira, J. C.; Lhiaubet-Vallet, V.; da Silva, A. R.; da Silva, A. M.; Ferreira, A. B. B.; Miranda, M. A.

    ”The Photochemical Reactivity of Triplet beta-Lapachone-3-sulfonic Acid towards Biological Substrates”

    J. Braz. Chem.Soc. (2010), 21, 966-972.

  • Alonso, R.; Yamaji, M.; Jimenez, M. C.; Miranda, M. A.

    ”Enhanced Photostability of the Anthracene Chromophore in Aqueous Medium upon Protein Encapsulation”

    J. Phys. Chem. B (2010), 114, 11363-11369.

  • Jornet, D.; Tormos, R.; Miranda, M. A.

    “Photobehavior of Mixed n pi*/pi pi* Triplets: Simultaneous Detection of the Two Transients, Solvent-Dependent Hydrogen Abstraction, and Reequilibration upon Protein Binding”

    J. Phys. Chem. B (2011), 115, 10768-10774.

  • Rohacova, J.; Sastre, G.; Marin, M. L.; Miranda, M. A.

    “Dansyl Labeling To Modulate the Relative Affinity of Bile Acids for the Binding Sites of Human Serum Albumin”

    J. Phys. Chem. B (2011), 115, 10518-10524.

  • Alonso, R.; Jimenez, M. C.; Miranda, M. A.

    “Stereodifferentiation in the Compartmentalized Photooxidation of a Protein-Bound Anthracene”

    Org. Lett. (2011), 13, 3860-3863.

  • Andreu, I.; Palumbo, F.; Tilocca, F.; Morera, I. M.; Bosca, F.; Miranda, M. A.

    “Solvent Effects in Hydrogen Abstraction from Cholesterol by Benzophenone Triplet Excited” State

    Org. Lett. (2011), 13, 4096-4099.

  • Andreu, I.; Neshchadin, D.; Rico, E.; Griesser, M.; Samadi, A.; Morera, I. M.; Gescheidt, G.; Miranda, M. A.

    “Probing Lipid Peroxidation by Using Linoleic Acid and Benzophenone”

    Chem. Eur. J. (2011), 17, 10089-10096.

  • Perez-Ruiz, R.; Alonso, R.; Nuin, E.; Andreu, I.; Jimenez, M. C.; Miranda, M. A.

    ”Naphthalene Triplet Excited State as a Probe for the Assessment of Drug Distribution in Binary Protein Systems”

    J. Phys. Chem. B( 2011), 115, 4460-4468.

  • Gomez-Mendoza, M.; Marin, M. L.; Miranda, M. A.

    Dansyl Derivatives of Cholic “Acid as Tools to Build Speciation Diagrams for Sodium Cholate Aggregation”

    J. Phys. Chem. Lett.( 2011), 2, 782-785.

  • Marin, M.; Lhiaubet-Vallet, V.; Miranda, M. A.

    “Site-Dependent Photo-Fries Rearrangement within Serum Albumins”

    J.Phys. Chem. B (2011), 115, 2910-2915.

  • Nuin, E.; Andreu, I.; Jose Torres, M.; Jimenez, M. C.; Miranda, M. A.

    “Enhanced Photosafety of Cinacalcet upon Complexation with Serum Albumin”

    J. Phys. Chem. B (2011), 115, 1158-1164.

  • Marin, M.; Lhiaubet-Vallet, V.; Paris, C.; Yamaji, M.; Miranda, M. A.

    ”Photochemical and photophysical properties of dibenzoylmethane derivatives within protein”

    Photochem. Photobiol. Sci. (2011), 10, 1474-1479.

  • Marin, M.; Lhiaubet-Vallet, V.; Miranda, M. A.

    ”Enhanced Photochemical 6 pi Electrocyclization within the Lipophilic Protein Binding Site”

    Org. Lett. (2012), 14, 1788-1791.

  • Marin, M. L.; Santos-Juanes, L.; Arques, A.; Amat, A. M.; Miranda, M. A.

    ”Organic Photocatalysts for the Oxidation of Pollutants and Model Compounds”

    Chem. Rev.( 2012), 112, 1710-1750.

  • Bartovsky, P.; Domingo, L. R.; Jornet, D.; Tormos, R.; Miranda, M. A.

    ”The triplet excited state of the bioactive compound thiabendazole. Characterization and suitability as reporter for cyclodextrin complexation”

    Chem. Phys. Lett.( 2012), 525-26, 166-170.

  • Soldevila, S.; Bosca, F.

    ”Photoreactivity of Fluoroquinolones: Nature of Aryl Cations Generated in Water”

    Org. Lett. (2012), 14, 3940-3943.

  • Cuquerella, M. C.; Andreu, I.; Soldevila, S.; Bosca, F.

    ”Triplet Excimers of Fluoroquinolones in Aqueous Media”

    J. Phys. Chem. A (2012), 116, 5030-5038.

  • Bonancía, P.; Vayá, I.; Climent, M. J.; Gustavsson, T.; Markovitsi, D.; Jiménez, M. C.; Miranda, M. A.

    ”Excited-State Interactions in Diastereomeric Flurbiprofen–Thymine Dyads”

    J. Phys. Chem. A (2012).

  • Bonancía, P.; Vigara, L.; Galindo, F.; Luis, S. V.; Jiménez, M. C.; Miranda, M.

    ”A. Triplet Excited State Behavior of Naphthalene-Based Pseudopeptides in the Presence of Energy Donors”

    J. Phys. Chem. B( 2012), 116, 9957 -9962.

  • Perez-Ruiz, R.; Saez, J. A.; Domingo, L. R.; Jimenez, M. C.; Miranda, M. A.

    ”Ring splitting of azetidin-2-ones via radical anions”

    Org. Biomol. Chem. (2012).

  • Gomez-Mendoza, M.; Nuin, E.; Andreu, I.; Marin, M. L.; Miranda, M. A.

    ”Photophysical Probes To Assess the Potential of Cholic Acid Aggregates as Drug Carriers”

    J. Phys. Chem. B (2012), 116, 10213-10218.

  • Bosca, F.

    ”Seeking to Shed Some Light on the Binding of Fluoroquinolones to Albumins”

    J. Phys. Chem. B (2012), 116, 3504-3511.